Universidad Nacional de La Plata

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1 to 10 of 931 Results

Observatorio de Valores del Suelo(CIC - LINTA - Lifia - ICJ - OPISU) Aug 31, 2026 El Observatorio es una iniciativa de articulación del sistema científico-técnico y el sector público provincial, cuyo propósito es relevar, sistematizar y producir información georreferenciada de valores inmobiliarios y promover el desarrollo de instrumentos de gestión de suelo u...
Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model Aug 28, 2026 - Facultad de Ciencias Médicas Mattiazzi, Alicia; Alejandra Cely-Ortiz; Juan Ignacion Felice; Elena Catalina Lascano; Carlos Alfredo Valverde; Luis Alberto Gonano; María Matilde Said; Cecilia Mundiña-Weilenmann, 2026, "Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model", https://datos.unlp.edu.ar/citation?persistentId=perma:10915dataset9XAGC5, Universidad Nacional de La Plata, V1, UNF:6:4Pjk1b/xfyT9Wa7JvC2RSw== [fileUNF] Cardiac alternans is a beat-to-beat oscillation in action potential duration and intracellular Ca²⁺ transients that develops at rapid heart rates and is associated with electrical instability and an increased risk of ventricular arrhythmias. The study uses a validated mathematica...
LEAME.md Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model Markdown Text - 18.9 KB - MD5: 4dc84b226051d323a5142cd9eda8197f Documentación Documento explicativo sobre lo que contiene este conjunto de datos.
README.md Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model Markdown Text - 17.2 KB - MD5: 115a67b7b73d79c671654fdde7f50f9d Documentación Explanatory document on what this dataset contains.
Supplemental Figs. S1-S8.pdf Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model Adobe PDF - 763.2 KB - MD5: ed77cc111d1a130f50cb043e1c25cfa5 Datos Compiled PDF containing all supplemental figures S1-S8.
Supplemental material.docx Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model MS Word - 21.5 KB - MD5: 6a6ad4bfc29d2d0db100dc70e57778e0 Documentación Detailed methodological description of the human ventricular myocyte mathematical model used in this study, including model structure (four compartments: cytoplasm, SR, DC1, DC2), ionic currents, Ca²⁺ handling mechanisms (RyR2 release, CICR, CaMKII regulation), and model equation...
figure_1_RyR2_model.png Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model PNG Image - 89.8 KB - MD5: c16252f14684aa4b0b3be8892cf08727 Datos Four-state Markov model of the RyR2. Modified from Shannon et al. (8). The channel can be found in 4 states: resting or closed (R), open (O), inactivated (I) and resting inactivated (RI). R, I, and RI are non-conducting states while O is the conducting state.
figure_2_150bpm_no_alt.png Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model PNG Image - 224.7 KB - MD5: 9ac51fea99ce7cbfe3af143fac3c9b6d Datos Increasing stimulation rate to 150 bpm does not evoke alternans. Increasing stimulation frequency up to 150 beats/min failed to produce Ca²⁺ alternans at 1.2 mM [Ca²⁺]ₒ. Only a few irregular beats are observed immediately after the frequency change.
figure_3_rabbit_alt_phases.png Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model PNG Image - 118.8 KB - MD5: b97d39db1f9d38dafa3571fb966d2e95 Datos Experimental results obtained by Picht et al. (10) in a rabbit myocyte stimulated at 2.0 Hz after complete depletion of SR with caffeine. The authors described a first phase without alternans (equivalent to our second phase), a third phase with alternans in which myocytes relaxed...
figure_4_APD_ICaL_recovery.png Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model PNG Image - 237.9 KB - MD5: 8689e3e02959f350ae1cc884dc22a476 Datos APD restitution and incomplete ICaL recovery support a predominantly voltage-driven mechanism during P1. (A) APD restitution curve as a function of the preceding diastolic interval (DI). Red symbols indicate the beats corresponding to the early alternating phase after the abrupt...

Observatorio de Valores del Suelo(CIC - LINTA - Lifia - ICJ - OPISU)

Aug 31, 2026

El Observatorio es una iniciativa de articulación del sistema científico-técnico y el sector público provincial, cuyo propósito es relevar, sistematizar y producir información georreferenciada de valores inmobiliarios y promover el desarrollo de instrumentos de gestión de suelo u...

Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

Aug 28, 2026 - Facultad de Ciencias Médicas

Mattiazzi, Alicia; Alejandra Cely-Ortiz; Juan Ignacion Felice; Elena Catalina Lascano; Carlos Alfredo Valverde; Luis Alberto Gonano; María Matilde Said; Cecilia Mundiña-Weilenmann, 2026, "Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model", https://datos.unlp.edu.ar/citation?persistentId=perma:10915dataset9XAGC5, Universidad Nacional de La Plata, V1, UNF:6:4Pjk1b/xfyT9Wa7JvC2RSw== [fileUNF]

Cardiac alternans is a beat-to-beat oscillation in action potential duration and intracellular Ca²⁺ transients that develops at rapid heart rates and is associated with electrical instability and an increased risk of ventricular arrhythmias. The study uses a validated mathematica...

LEAME.md

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

Markdown Text - 18.9 KB -

Documentación

Documento explicativo sobre lo que contiene este conjunto de datos.

README.md

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

Markdown Text - 17.2 KB -

Documentación

Explanatory document on what this dataset contains.

Supplemental Figs. S1-S8.pdf

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

Adobe PDF - 763.2 KB -

Datos

Compiled PDF containing all supplemental figures S1-S8.

Supplemental material.docx

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

MS Word - 21.5 KB -

Documentación

Detailed methodological description of the human ventricular myocyte mathematical model used in this study, including model structure (four compartments: cytoplasm, SR, DC1, DC2), ionic currents, Ca²⁺ handling mechanisms (RyR2 release, CICR, CaMKII regulation), and model equation...

figure_1_RyR2_model.png

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

PNG Image - 89.8 KB -

Datos

Four-state Markov model of the RyR2. Modified from Shannon et al. (8). The channel can be found in 4 states: resting or closed (R), open (O), inactivated (I) and resting inactivated (RI). R, I, and RI are non-conducting states while O is the conducting state.

figure_2_150bpm_no_alt.png

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

PNG Image - 224.7 KB -

Datos

Increasing stimulation rate to 150 bpm does not evoke alternans. Increasing stimulation frequency up to 150 beats/min failed to produce Ca²⁺ alternans at 1.2 mM [Ca²⁺]ₒ. Only a few irregular beats are observed immediately after the frequency change.

figure_3_rabbit_alt_phases.png

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

PNG Image - 118.8 KB -

Datos

Experimental results obtained by Picht et al. (10) in a rabbit myocyte stimulated at 2.0 Hz after complete depletion of SR with caffeine. The authors described a first phase without alternans (equivalent to our second phase), a third phase with alternans in which myocytes relaxed...

figure_4_APD_ICaL_recovery.png

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

PNG Image - 237.9 KB -

Datos

APD restitution and incomplete ICaL recovery support a predominantly voltage-driven mechanism during P1. (A) APD restitution curve as a function of the preceding diastolic interval (DI). Red symbols indicate the beats corresponding to the early alternating phase after the abrupt...

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