Universidad Nacional de La Plata

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Repositorio de Datos de la Universidad Nacional de La Plata, Argentina

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Facultad de Arquitectura y Urbanismo

Facultad de Periodismo y Comunicación Social

Facultad de Ciencias Exactas

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11 to 20 of 895 Results

figure_5b_BAPTA_AP_alt.png Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model PNG Image - 711.5 KB - MD5: 9af3032becfaecc5c396e42b93e99a10 Datos Experimental data from Warren and Poelzing (11), obtained in isolated rabbit ventricle myocytes, showing AP alternans induced by rapid pacing in the presence of BAPTA to abolish Ca²⁺ transients.
figure_6_CaMKII_FDAR.png Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model PNG Image - 93.7 KB - MD5: ec3a9070d07364ebd2aea440664c08de Datos The increase in stimulation frequency in the present simulations is associated with the described CaMKII-mediated increase in the velocity of relaxation (FDAR) (12,13). Red (70 bpm) and green (182 bpm) traces represent the exponential fit of the relaxation part of the calcium tra...
figure_7_SR_uptake_increase.png Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model PNG Image - 613.7 KB - MD5: d5b6f3f4581911701ee09d0cc41d9b2c Datos Increase in SR Ca²⁺ uptake velocity. SR Ca²⁺ uptake was increased by 50% at the beginning of P4 (arrow).
figure_8_FCR_alt_manipulation.png Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model PNG Image - 64.4 KB - MD5: 1b1449309ac5d5ceb49cc60a9f953285 Datos Effect of increasing SR Ca²⁺ uptake velocity on the Fractional Ca²⁺release (FCR). A. When Iup was enhanced 1.5 times (ocher triangles), shift SR Ca²⁺ content into a highly sensitive region of the FCR–load relation and alternans were exacerbated. Numbers indicate successive beats....
material_1_model_description.pdf Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model Adobe PDF - 105.6 KB - MD5: 7343bfd5fce53766a7eba857dca3d45c Documentación Detailed methodological description of the human ventricular myocyte mathematical model used in this study, including model structure (four compartments: cytoplasm, SR, DC1, DC2), ionic currents, Ca²⁺ handling mechanisms (RyR2 release, CICR, CaMKII regulation), and model equation...
table_ECC_params_RyR2_blocked.tab Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model Tabular Data - 1.9 KB - 15 Variables, 18 Observations - UNF:6:iIQ6xF4IA0gZROsoFfUZ6w== Datos Values of different ECC parameters in the first phase (P1) when SR Ca²⁺ release is abolished by blocking RyR2 channels. Under this condition the first phase extends from beat 4 to beat 18. Abbreviations as in Table 1.
table_ECC_params_RyR2_blocked_dict.tab Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model Tabular Data - 2.8 KB - 9 Variables, 15 Observations - UNF:6:lR40/z/fK2hjROwz5/cgBA== Documentación Data dictionary describing each variable in the table `table_ECC_params_RyR2_blocked`.
table_s2_150bpm_no_alt.tab Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model Tabular Data - 1.0 MB - 4 Variables, 35142 Observations - UNF:6:DLG4hZCDKBTDkGEq1dI79A== Datos Data from the simulation at 150 bpm that does not evoke alternans. Contains the temporal evolution of membrane potential (Vₘ), intracellular calcium ([Ca²⁺]ᵢ), and sarcoplasmic reticulum calcium ([Ca²⁺]ₛᵣ).
table_s2_150bpm_no_alt_dict.tab Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model Tabular Data - 397 B - 9 Variables, 4 Observations - UNF:6:vY5esTE5WJG9EJoQD26k+Q== Documentación Data dictionary describing each variable in the table `table_s2_150bpm_no_alt`.
table_s4a_APD_ICaL_recovery.tab Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model Tabular Data - 246 B - 1 Variables, 18 Observations - UNF:6:ooH0QZhyNZsegrEu2Vfrmw== Datos APD restitution curve (APD₉₀) as a function of the diastolic interval (DI).

figure_5b_BAPTA_AP_alt.png

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

PNG Image - 711.5 KB -

Datos

Experimental data from Warren and Poelzing (11), obtained in isolated rabbit ventricle myocytes, showing AP alternans induced by rapid pacing in the presence of BAPTA to abolish Ca²⁺ transients.

figure_6_CaMKII_FDAR.png

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

PNG Image - 93.7 KB -

Datos

The increase in stimulation frequency in the present simulations is associated with the described CaMKII-mediated increase in the velocity of relaxation (FDAR) (12,13). Red (70 bpm) and green (182 bpm) traces represent the exponential fit of the relaxation part of the calcium tra...

figure_7_SR_uptake_increase.png

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

PNG Image - 613.7 KB -

Datos

Increase in SR Ca²⁺ uptake velocity. SR Ca²⁺ uptake was increased by 50% at the beginning of P4 (arrow).

figure_8_FCR_alt_manipulation.png

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

PNG Image - 64.4 KB -

Datos

Effect of increasing SR Ca²⁺ uptake velocity on the Fractional Ca²⁺release (FCR). A. When Iup was enhanced 1.5 times (ocher triangles), shift SR Ca²⁺ content into a highly sensitive region of the FCR–load relation and alternans were exacerbated. Numbers indicate successive beats....

material_1_model_description.pdf

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

Adobe PDF - 105.6 KB -

Documentación

Detailed methodological description of the human ventricular myocyte mathematical model used in this study, including model structure (four compartments: cytoplasm, SR, DC1, DC2), ionic currents, Ca²⁺ handling mechanisms (RyR2 release, CICR, CaMKII regulation), and model equation...

table_ECC_params_RyR2_blocked.tab

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

Tabular Data - 1.9 KB - 15 Variables, 18 Observations -

Datos

Values of different ECC parameters in the first phase (P1) when SR Ca²⁺ release is abolished by blocking RyR2 channels. Under this condition the first phase extends from beat 4 to beat 18. Abbreviations as in Table 1.

table_ECC_params_RyR2_blocked_dict.tab

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

Tabular Data - 2.8 KB - 9 Variables, 15 Observations -

Documentación

Data dictionary describing each variable in the table `table_ECC_params_RyR2_blocked`.

table_s2_150bpm_no_alt.tab

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

Tabular Data - 1.0 MB - 4 Variables, 35142 Observations -

Datos

Data from the simulation at 150 bpm that does not evoke alternans. Contains the temporal evolution of membrane potential (Vₘ), intracellular calcium ([Ca²⁺]ᵢ), and sarcoplasmic reticulum calcium ([Ca²⁺]ₛᵣ).

table_s2_150bpm_no_alt_dict.tab

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

Tabular Data - 397 B - 9 Variables, 4 Observations -

Documentación

Data dictionary describing each variable in the table `table_s2_150bpm_no_alt`.

table_s4a_APD_ICaL_recovery.tab

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

Tabular Data - 246 B - 1 Variables, 18 Observations -

Datos

APD restitution curve (APD₉₀) as a function of the diastolic interval (DI).

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