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figure_1_RyR2_model.png Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model PNG Image - 89.8 KB - MD5: c16252f14684aa4b0b3be8892cf08727 Datos Four-state Markov model of the RyR2. Modified from Shannon et al. (8). The channel can be found in 4 states: resting or closed (R), open (O), inactivated (I) and resting inactivated (RI). R, I, and RI are non-conducting states while O is the conducting state.
figure_2_150bpm_no_alt.png Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model PNG Image - 224.7 KB - MD5: 9ac51fea99ce7cbfe3af143fac3c9b6d Datos Increasing stimulation rate to 150 bpm does not evoke alternans. Increasing stimulation frequency up to 150 beats/min failed to produce Ca²⁺ alternans at 1.2 mM [Ca²⁺]ₒ. Only a few irregular beats are observed immediately after the frequency change.
figure_3_rabbit_alt_phases.png Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model PNG Image - 118.8 KB - MD5: b97d39db1f9d38dafa3571fb966d2e95 Datos Experimental results obtained by Picht et al. (10) in a rabbit myocyte stimulated at 2.0 Hz after complete depletion of SR with caffeine. The authors described a first phase without alternans (equivalent to our second phase), a third phase with alternans in which myocytes relaxed...
figure_4_APD_ICaL_recovery.png Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model PNG Image - 237.9 KB - MD5: 8689e3e02959f350ae1cc884dc22a476 Datos APD restitution and incomplete ICaL recovery support a predominantly voltage-driven mechanism during P1. (A) APD restitution curve as a function of the preceding diastolic interval (DI). Red symbols indicate the beats corresponding to the early alternating phase after the abrupt...
figure_5a_RyR2_block_voltage_alt.png Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model PNG Image - 26.6 KB - MD5: b1bdbad2be4eab1f8134bb2f100df5be Datos Simulation of alternans at [Ca²⁺]ₒ = 2.0 mM in a human ventricular myocyte mathematical model in the presence of complete RyR2 blockade. The absence of CaT did not prevent voltage driven alternans, indicating that even at commonly used experimental [Ca²⁺]ₒ, Ca²⁺ cycling alternans...
figure_5b_BAPTA_AP_alt.png Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model PNG Image - 711.5 KB - MD5: 9af3032becfaecc5c396e42b93e99a10 Datos Experimental data from Warren and Poelzing (11), obtained in isolated rabbit ventricle myocytes, showing AP alternans induced by rapid pacing in the presence of BAPTA to abolish Ca²⁺ transients.
figure_6_CaMKII_FDAR.png Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model PNG Image - 93.7 KB - MD5: ec3a9070d07364ebd2aea440664c08de Datos The increase in stimulation frequency in the present simulations is associated with the described CaMKII-mediated increase in the velocity of relaxation (FDAR) (12,13). Red (70 bpm) and green (182 bpm) traces represent the exponential fit of the relaxation part of the calcium tra...
figure_7_SR_uptake_increase.png Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model PNG Image - 613.7 KB - MD5: d5b6f3f4581911701ee09d0cc41d9b2c Datos Increase in SR Ca²⁺ uptake velocity. SR Ca²⁺ uptake was increased by 50% at the beginning of P4 (arrow).
figure_8_FCR_alt_manipulation.png Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model PNG Image - 64.4 KB - MD5: 1b1449309ac5d5ceb49cc60a9f953285 Datos Effect of increasing SR Ca²⁺ uptake velocity on the Fractional Ca²⁺release (FCR). A. When Iup was enhanced 1.5 times (ocher triangles), shift SR Ca²⁺ content into a highly sensitive region of the FCR–load relation and alternans were exacerbated. Numbers indicate successive beats....
abachian_bedrossian_juan_carlos_8293245.jpg Aug 7, 2026 - Nómina de personas detenidas desaparecidas y/o asesinadas en el marco del terrorismo de Estado integrantes de la UNLP (2006) JPEG Image - 18.9 KB - MD5: 6970a4894b1bb679a424b5be3a905ced

figure_1_RyR2_model.png

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

PNG Image - 89.8 KB -

Datos

Four-state Markov model of the RyR2. Modified from Shannon et al. (8). The channel can be found in 4 states: resting or closed (R), open (O), inactivated (I) and resting inactivated (RI). R, I, and RI are non-conducting states while O is the conducting state.

figure_2_150bpm_no_alt.png

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

PNG Image - 224.7 KB -

Datos

Increasing stimulation rate to 150 bpm does not evoke alternans. Increasing stimulation frequency up to 150 beats/min failed to produce Ca²⁺ alternans at 1.2 mM [Ca²⁺]ₒ. Only a few irregular beats are observed immediately after the frequency change.

figure_3_rabbit_alt_phases.png

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

PNG Image - 118.8 KB -

Datos

Experimental results obtained by Picht et al. (10) in a rabbit myocyte stimulated at 2.0 Hz after complete depletion of SR with caffeine. The authors described a first phase without alternans (equivalent to our second phase), a third phase with alternans in which myocytes relaxed...

figure_4_APD_ICaL_recovery.png

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

PNG Image - 237.9 KB -

Datos

APD restitution and incomplete ICaL recovery support a predominantly voltage-driven mechanism during P1. (A) APD restitution curve as a function of the preceding diastolic interval (DI). Red symbols indicate the beats corresponding to the early alternating phase after the abrupt...

figure_5a_RyR2_block_voltage_alt.png

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

PNG Image - 26.6 KB -

Datos

Simulation of alternans at [Ca²⁺]ₒ = 2.0 mM in a human ventricular myocyte mathematical model in the presence of complete RyR2 blockade. The absence of CaT did not prevent voltage driven alternans, indicating that even at commonly used experimental [Ca²⁺]ₒ, Ca²⁺ cycling alternans...

figure_5b_BAPTA_AP_alt.png

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

PNG Image - 711.5 KB -

Datos

Experimental data from Warren and Poelzing (11), obtained in isolated rabbit ventricle myocytes, showing AP alternans induced by rapid pacing in the presence of BAPTA to abolish Ca²⁺ transients.

figure_6_CaMKII_FDAR.png

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

PNG Image - 93.7 KB -

Datos

The increase in stimulation frequency in the present simulations is associated with the described CaMKII-mediated increase in the velocity of relaxation (FDAR) (12,13). Red (70 bpm) and green (182 bpm) traces represent the exponential fit of the relaxation part of the calcium tra...

figure_7_SR_uptake_increase.png

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

PNG Image - 613.7 KB -

Datos

Increase in SR Ca²⁺ uptake velocity. SR Ca²⁺ uptake was increased by 50% at the beginning of P4 (arrow).

figure_8_FCR_alt_manipulation.png

Aug 28, 2026 - Mechanisms underlying cardiac alternans in a human ventricular myocyte mathematical model

PNG Image - 64.4 KB -

Datos

Effect of increasing SR Ca²⁺ uptake velocity on the Fractional Ca²⁺release (FCR). A. When Iup was enhanced 1.5 times (ocher triangles), shift SR Ca²⁺ content into a highly sensitive region of the FCR–load relation and alternans were exacerbated. Numbers indicate successive beats....

abachian_bedrossian_juan_carlos_8293245.jpg

Aug 7, 2026 - Nómina de personas detenidas desaparecidas y/o asesinadas en el marco del terrorismo de Estado integrantes de la UNLP (2006)

JPEG Image - 18.9 KB -

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