Statistical optimization, physicochemical characterization, in vitro release and pre-clinical PK of nanostructured lipid carriers loaded with stiripentol and cannabidiol

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Ruiz, Esperanza; Scioli Montoto, Sebastián; Talevi, Alan, 2026, "Statistical optimization, physicochemical characterization, in vitro release and pre-clinical PK of nanostructured lipid carriers loaded with stiripentol and cannabidiol", https://datos.unlp.edu.ar/citation?persistentId=perma:10915datasetT1OHFG, Universidad Nacional de La Plata, V1, UNF:6:H1XrHLbnRzZ+1jWKYAAp0w== [fileUNF]
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Description

The dataset contains the results of:

  • Formulation optimization: Central Composite Design (CCD).
  • Solid-state characterization:
    • Thermogravimetry (TGA)
    • Differential Scanning Calorimetry (DSC)
    • Fourier-Transform Infrared Spectroscopy (FTIR)
    • X-Ray Diffraction (XRD)
  • In vitro release: Dissolution testing under sink conditions.
  • Preclinical pharmacokinetics (PK): Murine model (BALB/c mice).

Drug concentrations were quantified by High-Performance Liquid Chromatography with Ultraviolet Detection (HPLC-UV).
The dataset includes raw instrumental outputs, processed concentration tables, and companion data dictionaries detailing variable names, units, and allowed values for each technique.

Subject Chemistry; Medicine, Health and Life Sciences
Keyword Nanoparticle Drug Delivery System, Stiripentol, Cannabidiol, Epilepsies, Myoclonic
Related Publication Scioli-Montoto, S., Lobos, M., Melis, M., Ruatta, S., Muraca, G., Chain, C. Y., Cisneros, S., Alvarez, V. A., Islan, G., Talevi, A., & Ruiz, M. E. Lipid Nanoparticles with Stiripentol and Cannabidiol Oil: From Rational Optimization to Preclinical Characterization. Pharmaceutics, 18(4), 503. 2026 doi: 10.3390/pharmaceutics18040503
Notes For each technique employed, a readme file is provided, containing a brief description of the experimental methodology and conditions, along with a data dictionary table file describing the variables included in the dataset. Other table files represent raw instrumental outputs and quantity/concentration data derived from the transformation of analytical signals (e.g., HPLC peak area) using appropriate calibration curves.
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CC BY-NC-SA 4.0

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LEAME.md
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README.md
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MD5: c3f8c8aec968809de827b5c96c86bbad
Explanatory document about what this dataset contains
release_data_dictionary.tab
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8 Variables, 5 Observations UNF:6:t4L7/YFOU4jtKEhISol6mg==
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release_data_formulations_and_controls.tab
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5 Variables, 49 Observations UNF:6:M/0ZgLOWg1noLAzbvinbrw==
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pk_data_dictionary.tab
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8 Variables, 5 Observations UNF:6:VHd7H6byzNx8aAE0h0bzzA==
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ftir_data_dictionary.tab
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